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VITAMIN D MAY NOT LOWER SENIORS FALL RISK

 Taking vitamin D supplements does little to reduce seniors’ risk of falls, a new review finds.

Researchers analyzed 20 studies that included nearly 30,000 people and tested how vitamin D supplements affected fall risk.

The results showed that the supplements did not reduce falls by 15 percent or more, which means they had little effect, according to Mark Bolland of the University of Auckland in New Zealand, and colleagues.

They concluded that there is insufficient evidence to support recommending vitamin D to seniors to lower their risk of falls, and also said that current ongoing studies investigating this theory are unlikely to change the conclusion.

The study was published in the April 23 issue of The Lancet Diabetes and Endocrinology journal.

The researchers noted that current evidence does not show whether taking vitamin D supplements might reduce falls in particularly vulnerable older people, such as those who fall often. This is because most studies examine only the total number of falls among all participants, rather than the number of falls per person.

Until now, some evidence that vitamin D supplements might prevent falls has led certain health organizations to recommend the use of the supplements, the review authors noted.

“Whether a large trial is feasible in this vulnerable population remains to be established. Until then, we are left with uncertainty about the benefits of vitamin D supplementation for reduction in fall risk, particularly among vulnerable older people,” Clifford Rosen, of the Maine Medical Research Institute, and Christine Taylor, of the U.S. National Institutes of Health, wrote in an accompanying commentary.

CROHNS AND COLITIS MAY BE TIED TO RISK OF HEART ATTACK STROKE

People with inflammatory bowel disease may be at increased risk for heart attack and stroke, a new study suggests.

Researchers analyzed data from more than 150,000 inflammatory bowel disease (IBD) patients who took part in nine studies. They found that these patients had a 10 percent to 25 percent increased risk of stroke and heart attack, and that this increased risk was more prevalent among women.

Doctors need to be aware of this link and should focus on controlling other stroke and heart attack risk factors, such as smoking, high blood pressure and diabetes, study author Siddharth Singh, of the Mayo Clinic in Rochester, Minn., said in a news release from the clinic.

The study was scheduled for presentation Monday at the annual meeting of the American College of Gastroenterology, in San Diego. Research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

Crohn’s disease and ulcerative colitis — the most common forms of IBD — affect 1.5 million Americans. In these patients, inflammation of the intestine leads to rectal bleeding, diarrhea, abdominal cramps and pain, fever, and weight loss.

Patients with IBD need to work with a doctor to manage their condition, control their stress, eat a healthy diet and get moderate exercise. Smoking is a major risk factor for IBD patients, and those who smoke should try to quit, the researchers said.

Although the study found an association between IBD and an increased risk for heart attack and stroke, it did not prove a cause-and-effect relationship.

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SLEEPING ON ANIMAL FUR IN INFANCY FOUND TO REDUCE RISK OF ASTHMA

Sleeping on animal fur in the first three months of life might reduce the risk of asthma in later childhood a new study has found.

The new research, presented at the European Respiratory Society (ERS) International Congress in Munich, suggests that exposure to the microbial environment in animal skin and fur could have a protective effect against asthma and allergies.

Previous studies have suggested that exposure to a wider range of environments from a young age could be protective against asthma and allergies. These findings have not been confirmed conclusively in urban settings. In this new study, researchers investigated children from a city environment who had been exposed to animal skin by sleeping on the material shortly after birth.

Data from a German birth cohort called Lisaplus were used. The cohort included over 3,000 healthy newborns who were mainly recruited in 1998.

The researchers collected information on exposure to animal skin during the first three months of life, along with information on the health of children until the age of 10 years. Information on 2,441 children was used in the study, with 55% of those included sleeping on animal skin in the first three months of life.

The results showed that sleeping on animal skin was associated with a reduced risk of a number of factors connected to asthma. The chance of having asthma at the age of 6 years was 79% lower in children who had slept on animal skin after birth compared with those who were not exposed to animal skin. The risk decreased to 41% by the age of 10.

Dr Christina Tischer, from the Helmholtz Zentrum München Research Centre, said: "Previous studies have suggested that microbes found in rural settings can protect from asthma. An animal skin might also be a reservoir for various kinds of microbes, following similar mechanisms as has been observed in rural environments. Our findings have confirmed that it is crucial to study further the actual microbial environment within the animal fur to confirm these associations."

BLOOD TEST MAY HELP DETERMINE WHO IS AT RISK FOR PSYCHOSIS

A study led by University of North Carolina at Chapel Hill researchers represents an important step forward in the accurate diagnosis of people who are experiencing the earliest stages of psychosis.

Psychosis includes hallucinations or delusions that define the development of severe mental disorders such as schizophrenia. Schizophrenia emerges in late adolescence and early adulthood and affects about 1 in every 100 people. In severe cases, the impact on a young person can be a life compromised, and the burden on family members can be almost as severe.

The study published in the journal Schizophrenia Bulletin reports preliminary results showing that a blood test, when used in psychiatric patients experiencing symptoms that are considered to be indicators of a high risk for psychosis, identifies those who later went on to develop psychosis.

"The blood test included a selection of 15 measures of immune and hormonal system imbalances as well as evidence of oxidative stress," said Diana O. Perkins, MD, MPH, professor of psychiatry in the UNC School of Medicine and corresponding author of the study. She is also medical director of UNC's Outreach and Support Intervention Services (OASIS) program for schizophrenia.

"While further research is required before this blood test could be clinically available, these results provide evidence regarding the fundamental nature of schizophrenia, and point towards novel pathways that could be targets for preventative interventions," Perkins said.

Clark D. Jeffries, PhD, bioinformatics scientist at the UNC-based Renaissance Computing Institute (RENCI), is a co-author of the study, which was conducted as part of the North American Prodrome Longitudinal Study (NAPLS), an international effort to understand risk factors and mechanisms for development of psychotic disorders.

"Modern, computer-based methods can readily discover seemingly clear patterns from nonsensical data," said Jeffries. "Added to that, scientific results from studies of complex disorders like schizophrenia can be confounded by many hidden dependencies. Thus, stringent testing is necessary to build a useful classifier. We did that."

The study concludes that the multiplex blood assay, if independently replicated and if integrated with studies of other classes of biomarkers, has the potential to be of high value in the clinical setting.

COFFEE DRINKERS HAVE LOWER RISK OF DEATH

Older adults who drank coffee -- caffeinated or decaffeinated -- had a lower risk of death overall than others who did not drink coffee, according a study by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, and AARP.

Coffee drinkers were less likely to die from heart disease, respiratory disease, stroke, injuries and accidents, diabetes, and infections, although the association was not seen for cancer. These results from a large study of older adults were observed after adjustment for the effects of other risk factors on mortality, such as smoking and alcohol consumption. Researchers caution, however, that they can't be sure whether these associations mean that drinking coffee actually makes people live longer. The results of the study were published in the May 17, 2012 edition of the New England Journal of Medicine.

Neal Freedman, Ph.D., Division of Cancer Epidemiology and Genetics, NCI, and his colleagues examined the association between coffee drinking and risk of death in 400,000 U.S. men and women ages 50 to 71 who participated in the NIH-AARP Diet and Health Study. Information about coffee intake was collected once by questionnaire at study entry in 1995-1996. The participants were followed until the date they died or Dec. 31, 2008, whichever came first.

The researchers found that the association between coffee and reduction in risk of death increased with the amount of coffee consumed. Relative to men and women who did not drink coffee, those who consumed three or more cups of coffee per day had approximately a 10 percent lower risk of death. Coffee drinking was not associated with cancer mortality among women, but there was a slight and only marginally statistically significant association of heavier coffee intake with increased risk of cancer death among men.

"Coffee is one of the most widely consumed beverages in America, but the association between coffee consumption and risk of death has been unclear. We found coffee consumption to be associated with lower risk of death overall, and of death from a number of different causes," said Freedman. "Although we cannot infer a causal relationship between coffee drinking and lower risk of death, we believe these results do provide some reassurance that coffee drinking does not adversely affect health."

The investigators caution that coffee intake was assessed by self-report at a single time point and therefore might not reflect long-term patterns of intake. Also, information was not available on how the coffee was prepared (espresso, boiled, filtered, etc.); the researchers consider it possible that preparation methods may affect the levels of any protective components in coffee.

"The mechanism by which coffee protects against risk of death -- if indeed the finding reflects a causal relationship -- is not clear, because coffee contains more than 1,000 compounds that might potentially affect health," said Freedman. "The most studied compound is caffeine, although our findings were similar in those who reported the majority of their coffee intake to be caffeinated or decaffeinated."